The global total COVID-19 cases has crossed the historic number of 163.1 million mark (163,162,133)and the daily global COVID-19 cases are increasing and yesterday it has registered a higher single day spike of over 6.2 lakh (627,221) cases with the single day deaths of 11,823 with 17,212,651 active COVID-19 cases on 15.5.21 with the global recovery rate of 98% and the death rate of 2%.Among total the currently infected global COVID-19 cases 99.4% were in mild clinical condition and about 0.6% were in critical condition as on 15.5.2021USA COVID-19 cases are declining and it has registered a single day spike of over 25k (25,642) COVID-19 cases and the total cases has crossed 33.6 mllion mark (33,695,916) with over 5.9 lakh (599,863) total deaths ( single day deaths of 499 with 5,997,433 active COVID-19 cases on 15.5.21.Brazil becomes third in the global list on 15.5.2021 and the total COVID-19 cases were with 15,590,613 and 434,852 deaths with the single day higher spike of 69,300 new cases and 2,067 newer deaths with 1,093,368 active COVID-19 cases on 15.5.2021In India over 180.4million (180,457,579) were vaccinated against COVID-19 as on 15.5.20210n 15.5.21 during the COVID-19 Pandemic India comes up to second place after USA in the global list of total COVID-19 cases and India becomes second after Brazil in global single day cases with the higher number of 310,822 cases on 15.5.21Cases and death rate in India Tamilnadu and in Trichy are in raise again as second wave and India's higher single day spike of COVID-19 over 3.1 lakh (310,822) with the higher deaths of 4,090 and the total has crossed 24.6 million mark (24,683,065) on 15.5.21 during this Pandemic. The recovered cases were second to U.S over 20.7 million mark (20,789,038) and the active COVID-19 cases are 3,623,708 as of 15.5.21.As of 16.5.21 in 220 countries ( Saint Helena is the 220th country added on 25.4.21 )and territories has recorded over 163.1 Million mark (163,169,300) cases with India over 24.6Million mark (24,683,065) with 33,658 new cases and the total crosses 1.5 million mark (1,560,035) with 207,789 active COVID-19 cases in the State of Tamilnadu , and in Trichy 1263 new cases and the total crosses 36k (35,398) with 6328 active cases cases were reported with COVID-19 infection .Recovered cases were over 141,4Million mark (141,466,636) and over 3.3 million mark (3,383,265) deaths in world which has crossed 2.7 lakh mark (270,319) in India and 303 (T 17,359 in Tamilnadu and 11(T327)at Trichy has been recorded as of 16.5.2021.M.A.Aleem Neurologist Trichy Tamilnadu India