Erectile Dysfunction Drugs Beneficial in DMD

Recent study indicate that drugs such as tadalafil and sildenafil that inhibit phosphodiesterase type 5 (PDE5) may represent a promising new treatment strategy for boys with Duchenne muscular dystrophy (DMD).
Functional sympatholysis, a protective mechanism that matches oxygen delivery to metabolic demand, is impaired in patients with DMD, producing functional muscle ischemia despite corticosteroid and/or cardioprotective therapy. Researchers now report that tadalafil alleviates this ischemia in a dose-dependent manner.
Sildenafil, another PDE5 inhibitor, replicated the effect of tadalafil, strongly supporting PDE5 inhibition as the mechanism of action.
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