The global total COVID-19 cases has crossed the historic number of 161 million mark (161,077,595)and the daily global COVID-19 cases are increasing and yesterday it has registered a higher single day spike of over 7.5 lakh (751,488) cases with the single day deaths of 13,843 with 17,884,958 active COVID-19 cases on 12.5.21 with the global recovery rate of 98% and the death rate of 2%.Among total the currently infected global COVID-19 cases 99.4% were in mild clinical condition and about 0.6% were in critical condition as on 12.5.2021USA COVID-19 cases are declining and it has registered a single day spike of over 35k (35,816) COVID-19 cases and the total cases has crossed 33.5 mllion mark (33,586,136) with over 5.9 lakh (597,785) total deaths ( single day deaths of 841 with 6,368,122 active COVID-19 cases on 13.5.21.Brazil becomes third in the global list on 12.5.2021 and the total COVID-19 cases were with 15,361,686 and 428,256 deaths with the single day spike of 76,638 new cases and 2,545 newer deaths with 1,008,213 active COVID-19 cases on 12.5.2021In India over 175.2 million (175,235,991) were vaccinated against COVID-19 as on 12.5.20210n 12.5.21 during the COVID-19 Pandemic India comes up to second place after USA in the global list of total COVID-19 cases and India becomes second after Brazil in global single day cases with the higher number of 362,406 cases on 12.5.21Cases and death rate in India Tamilnadu and in Trichy are in raise again as second wave and India's higher single day spike of COVID-19 over 3.6 lakh (362,406) with the higher deaths of 4,126 and the total has crossed 23.7 million mark (23,702,832) on 12.5.21 during this Pandemic. The recovered cases were second to U.S over 19.7 million mark (19,728,436) and the active COVID-19 cases are 3,716,045 as of 12.5.21.As of 13.5.21 in 220 countries ( Saint Helena is the 220th country added on 25.4.21 )and territories has recorded over 161 Million mark (161,081,448) cases with India over 23.7Million mark (23,702,832) with 30,355 new cases and the total crosses 1.4 million mark (1,464,864) with 162,471 active COVID-19 cases in the State of Tamilnadu , and in Trichy 879 new cases and the total crosses 31k (31,973) with 5434 active cases cases were reported with COVID-19 infection .Recovered cases were over 138.8 Million mark (138,864,595) and over 3.3 million mark (3,345,035) deaths in world which has crossed 2.5 lakh mark (258,351) in India and 293 (T 16,471) in Tamilnadu and 12(T 298)at Trichy has been recorded as of 13.5.2021.M.A.Aleem Neurologist Trichy Tamilnadu India